Protein Details: Small conductance calcium-activated potassium channel protein 1
Protein ID
ICDB_Pro_1378
Protein Name
Small conductance calcium-activated potassium channel protein 1
Gene Name
KCNN1; SK
Organism
Homo sapiens (Human)
Length
543 amino acids
AlphaFoldDB
AF-Q92952-F1-model_v4.pdb
Function
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)
Sequence
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
PDB Structures
Ligand Binding
Binding Site
Disease
Atrial Fibrillation and Episodic Ataxia
Location
DOI ID
10.1126/science.273.5282.1709; 10.1159/000015415; 10.1101/gr.2596504; 10.1074/jbc.272.37.23195; 10.1074/jbc.m607213200
RefSeq
NP_002239.2 [Q92952-1]